Buprefelican Multidose 0.3 mg/ml solution for injection for dogs and cats

Intramuscular or intravenous use.

Dogs:           Post-operative analgesia, potentiation of the sedation.
             10 - 20 µg/kg (0.3 - 0.6 ml per 10 kg)

Cats:        Post-operative analgesia.
             10 - 20 µg/kg (0.3 - 0.6 ml per 10 kg)

For further pain relief the dose may be repeated if necessary:
Dogs:        either after 3 - 4 hours with 10 µg/kg        (0.3 ml per 10 kg)
             or     after 5 - 6 hours with 20 µg/kg        (0.6 ml per 10 kg)

Cats: Once, after 1 - 2 hours with 10 – 20 µg/kg      (0.3 - 0.6 ml per 10 kg)

While sedative effects are present by 15 minutes after administration, analgesic activity becomes
apparent after approximately 30 minutes. To ensure that analgesia is present during surgery and
immediately on recovery, the veterinary medicinal product should be administered preoperatively as
part of premedication.
When administered for potentiation of sedation or as part of premedication, the dose of other centrally-
acting agents, such as acepromazine or medetomidine, should be reduced. The reduction will depend
on the degree of sedation required, the individual animal, the type of other agents included in
premedication and how anaesthesia is to be induced and maintained. It may also be possible to reduce
the amount of inhalational anaesthetic used.

Animals administered opioids possessing sedative and analgesic properties may show variable
responses. Therefore, the response of individual animals should be monitored and subsequent doses
should be adjusted accordingly. In some cases, repeat doses may fail to provide additional analgesia.
In these cases, consideration should be given to using a suitable injectable NSAID.
An appropriately graduated syringe must be used to allow accurate dosing. The closure must not be
punctured more than 100 times (with a 21G or 23G needle).